EXAMINE THIS REPORT ON LSD CRYSTAL

Within the LSD-sure crystal composition, the facet chain of the lid residue L209EL2 types intensive hydrophobic contacts with the two LSD and surrounding residues in TMs III, IV, and V (Determine 4C). If the lid moved aside to expose the binding pocket in simulation, many of those contacts broke. We Therefore hypothesized that L209EL2 acts like a l